Our Mission

Established in 2013, the Oklahoma Clinical and Translational Science Institute serves as a catalyst for clinical and translational research that improves health and healthcare for Oklahomans, to provide training and infrastructure to help junior investigators to launch independent research careers, and to expand the opportunities of IDeA states and Oklahoma communities to participate in research that improves the health of our residents. 

Oklahoma Shared Clinical and Translational Resources

OSCTR is Oklahoma's NIH-funded IDeA-CTR that provides resources, information, and training to help individuals or communities involved in performing clinical and translational research in the state

Oklahoma Primary Healthcare Improvement Cooperative

 

OPHIC is the implementation science arm of a statewide network to help improve healthcare delivery assisting primary care practices to adopt evidence-based best practices for the care of their patients.

OCTSI Clinical Research Unit

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The OCTSI CRU assists medical providers to identify and conduct clinical research opportunities in Oklahoma.

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University of Oklahoma Health Sciences Receives Federal Funding to Improve Health Care Access Across the State

Submitted by alex on

Across large areas of Oklahoma and the nation, primary care clinics are a lifeline, providing care for people who otherwise would have to travel many miles to see a doctor. To increase access to vital health care, the National Institutes of Health announced an ambitious new initiative to integrate NIH-funded clinical trials into routine patient care in areas like rural Oklahoma and within Tribal nations.

OU Awarded $17 Million NIH Grant to Improve Cancer Outcomes Among Native Americans

Submitted by Anonymous (not verified) on

The National Institutes of Health has awarded the University of Oklahoma a five-year, $17.2 million grant to partner with tribal nations and communities to improve cancer outcomes. Research has shown that the American Indian and Alaska Native population in Oklahoma experiences a 36% higher incidence of cancer and a 73% higher death rate from cancer than faced by the U.S. general population.

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Recent Publications

Surfactant proteins A and D nucleotide variants: association with retinal vascular disease

Pediatr Res. 2025 Oct 16:10.1038/s41390-025-04435-w. doi: 10.1038/s41390-025-04435-w. Online ahead of print.

ABSTRACT

BACKGROUND: Retinopathy of prematurity (ROP) is associated with systemic inflammation. Surfactant proteins A and D (SP-A and SP-D) play an immunomodulatory role. We previously reported the impact of SP-A on retinal angiogenesis. This study investigates SP-A and SP-D single-nucleotide polymorphisms (SNPs) with risk of ROP.

Quantifying the Drivers of Survival: A Matched Cohort Study of Trauma Center-Level Differences

J Surg Res. 2025 Oct 22;315:688-698. doi: 10.1016/j.jss.2025.09.071. Online ahead of print.

ABSTRACT

INTRODUCTION: Tertiary trauma centers (levels I and II) offer comprehensive care and are equipped to manage complex injuries. Trauma patients treated at tertiary centers have better survival outcomes. However, the specific interventions driving this advantage remain unknown. This study aimed to identify interventions contributing to differences in short-term mortality between tertiary trauma centers (TTCs) and nontertiary trauma centers (NTCs).

Effect of Paxlovid treatment during acute COVID-19 on Long COVID onset: An EHR-based target trial emulation from the N3C and RECOVER consortia

PLoS Med. 2025 Sep 15;22(9):e1004711. doi: 10.1371/journal.pmed.1004711. eCollection 2025 Sep.

ABSTRACT

BACKGROUND: Preventing and treating post-acute sequelae of COVID-19 infection (PASC), commonly known as Long COVID, has become a public health priority. This study tests whether Paxlovid treatment in the acute phase of COVID-19 could help prevent the onset of PASC.

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