Dysregulated long non-coding RNA in Sjögren's disease impacts both interferon and adaptive immune responses
RMD Open. 2022 Nov;8(2):e002672. doi: 10.1136/rmdopen-2022-002672.
ABSTRACT
OBJECTIVE: Sjögren's disease (SjD) is an autoimmune disease characterised by inflammatory destruction of exocrine glands. Patients with autoantibodies to Ro/SSA (SjDRo+) exhibit more severe disease. Long non-coding RNAs (lncRNAs) are a functionally diverse class of non-protein-coding RNAs whose role in autoimmune disease pathology has not been well characterised.